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6.0% (42 mmol/mol) and for those in the standard-therapy group with a concentration of less than 9.0% (75 mmol/mol) before any change in oral medications. Subsequent changes in medication were determined according to protocol guidelines and local assessment. The goal for the HbA1c concentrations was an absolute reduction of 1.5 percentage points in the intensive-therapy group as compared with the standard-therapy group [92].. A total of 799 patients were enrolled; 79.5% of patients underwent imaging. Twenty-seven had ICIs (3.4%). Fourteen had subdural hematoma, 7 had subarachnoid hemorrhage, 3 had cerebral contusion, and 3 had a combination of injuries. Logistic regression demonstrated 2 study variables that were associated with ICIs: LOC (odds ratio, 2.8; confidence interval, 1.2-6.3) and signs of head trauma (odds ratio, 13.2; confidence interval, 2.7-64.1). History of head strike, mechanism and position, headache, and anticoagulant and antiplatelet use were not associated with ICIs.
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