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The high incidence of gastrointestinal cancers in the Kashmir Valley has been attributed to the presence of many chemical carcinogens such as nitrosamines and heterocyclic amines in tobacco and salted tea. Due to functional polymorphisms of the N-acetyltransferase 2 (NAT2) gene, there may be interindividual differences in the metabolism of heterocyclic amines. We undertook this study to determine the influence of NAT2 gene polymorphisms (rs1799929, rs1799930, rs1799931) as well as their interactions with environmental carcinogens on the modulation of risk of esophageal and gastric cancers (EC and GC) in the Kashmir Valley.. performed a progressive and significant counterclockwise displacement.

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Phylogenetic analysis: Characterization of B19 isolates was examined by the phylogenetic analysis as described previously [4]. The data were analyzed using a standard statistical software package (Stat View; Brain Power Inc., Calabases, CA, U.S.A.).. We further performed multivariate logistic regression analyses with a backward stepwise approach for presence of bone turnover subtypes 2B, 3, 4A and 4B, including in the models the following variables: dementia, CHF, anaemia, CKD, history of malignancy, DM, vitamin D status, hyperparathyroidism, hypoalbuminaemia, use of walking aids, RCF residence, alcohol overuse, smoking (current and previous), use of anti-resorptive medications (>3 months), gender and age; age was evaluated as a continuous and as a categorical(>75 years) variable in separate models. As can be seen in Table 3, following these analyses, subtype 2B was independently predicted by 2 variables, subtype 3 by 6 variables, subtype 4A by 6, and subtype 4B by 4 variables. For every year increase in age there was a 6% increase in probability of subtype 3 and a 5% increase in probability of subtype 4B. Compared to subjects with subtypes 1 and 2A, among aged>75 years the presence of subtype 2B was 1.9-fold higher and presence of subtypes 3 and 4B was 2.5-fold higher. Hyperparthyroidism was the only other independent predictor for subtype 2B. For subtypes 3, 4A and 4B hypoalbuminaemia on admission was a significant independent positive indicator while use of osteoporotic treatment was an independent negative predictor. Anaemia and history of malignancy were independent predictors of subtypes3 and 4A, presence of CHF strongly indicated subtype3, and CKD correlated independently with subtypes 4A and 4B.. bone-implant system.

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